Diabetes Care：姜黄素可降低2型糖尿病的发病率

最新研究证实姜黄素中一种成分可以降低2型糖尿病的发病率，改善成年人糖尿病前期β细胞的功能，相关研究论文发表在Diabetes Care杂志上。

医师Somlak Chuengsamarn与同事随机分配240例糖尿病前期成人口服姜黄素或安慰剂，每天两次共接受九个月治疗。治疗后对这些人2型糖尿病进展进行了评估分析。

九个月后，研究人员发现16.4％的安慰剂组患上了糖尿病，姜黄素组无一人患2型糖尿病的。姜黄素治疗后能显著改善β细胞的功能。

总之结论支持：一个糖尿病前期患者服用9个月的姜黄素能显著降低患2型糖尿病的风险。此外，姜黄素治疗能改善β细胞的整体功能，而姜黄素的不利影响却非常少。

泰国政府制药组织为这项研究提供了姜黄素提取物和安慰剂。

doi:10.2337/dc12-0116
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Curcumin Extract for Prevention of Type 2 Diabetes

Somlak Chuengsamarn, MD1,2, Suthee Rattanamongkolgul, MD3, Rataya Luechapudiporn, PHD4, Chada Phisalaphong, PHD5 and Siwanon Jirawatnotai, PHD6,7

OBJECTIVE To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetes population.

RESEARCH DESIGN AND METHODS This randomized, double-blinded, placebo- controlled trial included subjects (n = 240) with criteria of prediabetes. All subjects were randomly assigned to receive either curcumin or placebo capsules for 9 months. To assess the T2DM progression after curcumin treatments and to determine the number of subjects progressing to T2DM, changes in β-cell functions (homeostasis model assessment [HOMA]-β, C-peptide, and proinsulin/insulin), insulin resistance (HOMA-IR), anti-inflammatory cytokine (adiponectin), and other parameters were monitored at the baseline and at 3-, 6-, and 9-month visits during the course of intervention.

RESULTS After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group.

CONCLUSIONS A 9-month curcumin intervention of a prediabetes population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of β-cells, with very minor adverse effects. Therefore, this study demonstrated that the curcumin intervention in a prediabetes population may be beneficial.