MMP-2与梗死面积/左室功能障碍相关

2011-07-14 MedSci原创 MedSci原创

MMP-2PCI心肌梗死

　瑞典一项研究表明，对于 ST段抬高性心肌梗死（STEMI）患者，再灌注早期或之前测得的循环基质金属蛋白酶2（MMP-2）水平与梗死面积和左心室功能障碍显著相关。 　　研究纳入58例接受直接经皮冠状动脉介入术（PCI）的STEMI患者， 结果显示，0小时和12 小时患者血浆MMP-2水平与5天和4个月时测得心肌梗死面积及左心室功能障碍显著相关，且与肌钙蛋白I水平相关

　瑞典一项研究表明，对于 ST段抬高性心肌梗死（STEMI）患者，再灌注早期或之前测得的循环基质金属蛋白酶2（MMP-2）水平与梗死面积和左心室功能障碍显著相关。

　　研究纳入58例接受直接经皮冠状动脉介入术（PCI）的STEMI患者， 结果显示，0小时和12 小时患者血浆MMP-2水平与5天和4个月时测得心肌梗死面积及左心室功能障碍显著相关，且与肌钙蛋白I水平相关。该研究7月4日在线发表于《心脏》（Heart）杂志。

原始文献：

Nilsson L, Hallén J, Atar D, Jonasson L, Swahn E.Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction.Heart. 2011 Jul 4.
 
Abstract

Background Immediate reopening of the acutely occluded infarct-related artery via primary PCI is the preferred treatment in ST-elevation myocardial infarction (STEMI). However, the sudden reinitiation of blood flow can lead to a local acute inflammatory response with further endothelial and myocardial damage, so-called reperfusion injury. The activation of matrix metalloproteinases (MMPs) is suggested to be a key event in this process. Objectives To investigate circulating MMPs, tissue inhibitors of metalloproteinases (TIMPs) and myeloperoxidase (MPO) in relation to infarct size, left ventricular dysfunction and remodelling in a STEMI population undergoing PCI. Methods 58 Patients with STEMI undergoing primary PCI were included. Blood samples were collected at baseline before PCI and at 12, 24 and 48 h for later analysis of MMPs, TIMPs and MPO by ELISA. Infarct size, left ventricular (LV) dysfunction and remodelling were assessed by cardiac MRI at 5 days and 4 month after STEMI. Results Plasma MMP-2 at 0 and 12 h showed a consistent and significant correlation with infarct size and LV dysfunction measured both at 5 days and at 4 months and correlated well with troponin I measurements. For TIMP-1 and TIMP-2 some support was found for associations with infarct size and LV dysfunction, but these were not as consistent as for MMP-2. MMP-8, MMP-9 and MPO did not overall correlate with measures of infarct size, LV dysfunction or remodelling. Conclusions In patients with STEMI, circulating levels of MMP-2, measured early and even before reperfusion therapy, are strongly associated with infarct size and LV dysfunction. This provides further evidence for the role of MMP-2 in ischaemia-reperfusion injury.



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评论区 (5)
#插入话题
  1. 2011-08-03 wjcjjian

    #左室功能#

    0

  2. 2011-10-03 juliusluan86

    #MMP-2#

    0

  3. 2011-10-26 arlian1977

    出发点很新颖

    0

  4. 2011-10-09 gaozy777

    基质金属蛋白酶（MMP）与冠心病之间的关系早有大量文献，MMP家族到目前为止有近30个成员，因此，选取MMP-2研究冠心病也就不足为奇了！

    0

  5. 2011-07-16 naiwu78

    #功能障碍#

    0