JCEM:糖尿病患者重听可能性或为健康人群的2倍

2012-12-05 佚名 纽约路透

重听糖尿病患者听力受损

　　（纽约路透电）糖尿病已被认为与肾脏和心血管疾病、神经受损和失明有关联，但日本科研人员现在也发现，糖尿病患者重听的可能性是非患者的2倍。 　　刊登在《临床内分泌代谢》期刊（Journal of Clinical Endocrinology and Metabolism）上的这份研究报告也指出，较年轻糖尿病患者出现听力障碍的风险比年长患者来得高，但科研人员无法解释为何如此。 　　科研人员收集了

　　（纽约路透电）糖尿病已被认为与肾脏和心血管疾病、神经受损和失明有关联，但日本科研人员现在也发现，糖尿病患者重听的可能性是非患者的2倍。

　　刊登在《临床内分泌代谢》期刊（Journal of Clinical Endocrinology and Metabolism）上的这份研究报告也指出，较年轻糖尿病患者出现听力障碍的风险比年长患者来得高，但科研人员无法解释为何如此。

　　科研人员收集了1974年至2011年间刊登的有关糖尿病与听力受损的13项研究的资料，里面的研究对象包括7377个糖尿病病人和1万2817个健康人士。

　　研究人员发现，糖尿病病人重听的可能性是一般人的2.15倍。但如果根据年龄区分，60岁以下人士重听的风险是2.61倍，60岁以上人士则是1.58倍。

　　领导该研究的日本新潟大学医学院的堀川说，这可能是伴随着糖尿病的高血糖会损害耳朵里的血管，进而造成听力受损。

　　不过，研究人员认为，未来还有必要展开更多研究，例如把年龄和周遭环境的吵杂程度考虑在内，才能确定糖尿病与听力受损之间的关联。

　　与此同时也有专家认为，有关研究并不能证明，糖尿病与听力受损之间有直接关联。

　　美国糖尿病专家史密斯说，有关研究没有明确回答糖尿病与听力受损是否有直接关联，但是提出了患者可能询问的问题。



Context
Recently, several studies have investigated the relationship between diabetes and hearing impairment, but results were inconsistent.
Objective
Our objective was to compare the prevalence of hearing impairment between diabetic and nondiabetic adults.
Data Sources
We performed a systematic literature search using MEDLINE (1950 to May 30, 2011) and EMBASE (1974 to May 30, 2011).
Study Selection
Cross-sectional studies were included if data on numbers of hearing-impaired and non-hearing-impaired cases with diabetes were presented. Hearing impairment was limited to that assessed by pure-tone audiometry that included at least 2 kHz of frequency range and was defined as progressive, chronic, sensorineural, or without specified cause.
Data Extraction
Two authors independently extracted relevant data. Odd ratios (ORs) of hearing impairment related to diabetes calculated in each study were pooled with the random-effects model.
Data Synthesis
Data were obtained from 13 eligible studies (20,194 participants and 7,377 cases). Overall pooled OR (95% confidence interval) of hearing impairment for diabetic participants compared with nondiabetic participants was 2.15 (1.72–2.68). OR was higher in younger participants (mean age, ≤60 yr) than in those over 60 yr among which the OR remained significant (2.61 and 1.58, P = 0.008). The strength of the association between diabetes and prevalence of hearing impairment was not significantly influenced by whether participants were matched for age and gender (P = 0.68) or whether participants chronically exposed to noisy environments were excluded (P = 0.19).
Conclusions
Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age.    

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