日本研发出线状细胞组织 有望用于移植医疗

日本《每日新闻》4月2日消息，日本东京大学生产技术研究所在3月31日出版的英国科学杂志《Nature materials》电子版上发表论文宣布，已研制出某种线状细胞组织，该组织直径纤细约0.1cm，伸展后长度却能达1米以上。

报道称，由老鼠的神经细胞组成的线状组织，细胞的正常运转已得到确认。可以应用于移植医疗领域。

研究团队将细胞和骨胶原的混合溶液填入胶状细管中进行培养，再将已结合的细胞组织外侧的细管溶解，就能得到不易被破坏的细胞组织。

日本同志社大学副教授竹内昌治称，“将细胞像织布一样（二维）组合就能得到一张细胞薄网，未来将会制作更为复杂的立体细胞”。

doi:10.1038/nmat3606
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Metre-long cell-laden microfibres exhibit tissue morphologies and functions

Hiroaki Onoe, Teru Okitsu, Akane Itou, Midori Kato-Negishi, Riho Gojo, Daisuke Kiriya, Koji Sato, Shigenori Miura, Shintaroh Iwanaga, Kaori Kuribayashi-Shigetomi, Yukiko T. Matsunaga, Yuto Shimoyama & Shoji Takeuchi

Artificial reconstruction of fibre-shaped cellular constructs could greatly contribute to tissue assembly in vitro. Here we show that, by using a microfluidic device with double-coaxial laminar flow, metre-long core–shell hydrogel microfibres encapsulating ECM proteins and differentiated cells or somatic stem cells can be fabricated, and that the microfibres reconstitute intrinsic morphologies and functions of living tissues. We also show that these functional fibres can be assembled, by weaving and reeling, into macroscopic cellular structures with various spatial patterns. Moreover, fibres encapsulating primary pancreatic islet cells and transplanted through a microcatheter into the subrenal capsular space of diabetic mice normalized blood glucose concentrations for about two weeks. These microfibres may find use as templates for the reconstruction of fibre-shaped functional tissues that mimic muscle fibres, blood vessels or nerve networks in vivo.

(责任编辑：lili.zhao)