Depress Anxiety：预防抑郁症和自杀应处理焦虑症状

　　澳大利亚一项研究表明，抑郁症和自杀预防计划除了应包括减轻抑郁症状外，还应包括减轻焦虑症状，应针对性处理患者报告的诸如担忧或烦躁不安等症状。该研究论文3月14日在线发表于《抑郁与焦虑》（Depress Anxiety）杂志。

　　相对于抑郁症状，焦虑症状在抑郁症和自杀意念的进展中发挥的作用尚不十分清楚。该研究的目的是在人群水平上确定焦虑和抑郁症状对抑郁症的发病和自杀意念的产生贡献最大。

　　该研究是澳大利亚一项基于社区的纵向队列研究，纳入了7485名年轻成人、中年人和老年人。

　　结果显示，焦虑症状对抑郁症（45％）的发病和自杀意念（23％）的产生的贡献大于抑郁症状（分别为35％和16％）。在年轻组，焦虑症状对偶发性抑郁症和自杀意念的人群归因危险度最高。

与抑郁相关的拓展阅读：

• 冠状动脉旁路移植术前后应监测抑郁
• JAMA Psychiatry：CRP 水平升高或与抑郁症发病相关
• Neuroscience Bulletin ：发现疑似抑郁易感基因
• Lancet:认知行为疗法辅助治疗抵抗性抑郁症有效
• Science:揭示长期压力导致抑郁症的神经机制
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ANXIETY SYMPTOMS AS PRECURSORS OF MAJOR DEPRESSION AND SUICIDAL IDEATION

Background

Relative to depression symptoms, the role of anxiety symptoms in the development of depression and suicidal ideation has not been well established. This study aimed to identify the anxiety and depression symptoms that confer the greatest amount of risk for depression and suicidal ideation at the population level.

Method

The PATH through Life study is an Australian community-based longitudinal cohort study of 7,485 younger, middle-aged, and older adults. Adjusted population attributable risk (PAR) for incident depression and suicidal ideation after 4 years was assessed for 18 symptoms of anxiety and depression.

Results

Anxiety symptoms contributed greater risk overall to both depression (45%) and suicidal ideation (23%) incidence than depression symptoms (35% and 16%, respectively). Anxiety symptoms had largest PARs among younger age groups.

Conclusions

Prevention programs for depression and suicide should aim to reduce anxiety symptoms in addition to depression symptoms, and target individuals reporting symptoms such as worrying or irritability.