Sci Total Envir：年轻人需警惕致癌性的皮肤损伤

近日，来自昆士兰理工大学（QUT）的研究者研究发现，在年轻人一生中，他们遭受了高风险的皮肤损伤，研究者Michael Kimlin表示，在人一生中第一个18年暴露于UV中，可以明显引起致癌的皮肤损伤和皮肤衰老。研究者表示，当人们年龄超过50岁，皮肤退化的比例最低，但是这个时候仍然得警惕皮肤损伤，因此在人一生中，进行日晒防护是必不可少的。研究者的相关研究成果刊登在了近期的杂志Science of The Total Environment上。

这项研究中，研究者使用了一种独特的非侵入性的“UV照相机”，这种照相机可以对肉眼看不到的皮肤损伤和老化进行拍照，研究者又测定了日光暴露时间和皮肤癌风险之间的关系。Kimlin表示，皮肤伤害大多数发生在日光照射的初期几年，在50岁之后皮肤损伤会慢慢增加，我们又研究了年龄对皮肤损伤的影响，发现它们之间并不是单一的关系。

研究数据显示，当我们在青少年时期就要好好保护皮肤，以免皮肤起皱纹以及皮肤损伤。在青少年时期要进行有效的日光保护措施以维持我们皮肤的健康。

研究者用UV照相机对180名18至83岁的人群皮肤进行拍照，并且分析这些研究对象日光暴露的水平，研究人员测定了研究对象的皮肤着色程度（hyoerpigmentation）来判断皮肤随上和褶皱的水平，用以预示皮肤的衰老程度。最后，Kimlin教授表示，人们应该进行必要的皮肤癌风险检测以早日防范。

doi:10.1016/j.scitotenv.2012.02.080
PMC:
PMID:

Assessing the impacts of lifetime sun exposure on skin damage and skin aging using a non-invasive method

Michael G. Kimlin, , Yuming Guo,

Background Ultraviolet radiation exposure during an individuals' lifetime is a known risk factor for the development of skin cancer. However, less evidence is available on assessing the relationship between lifetime sun exposure and skin damage and skin aging.

Objectives This study aims to assess the relationship between lifetime sun exposure and skin damage and skin aging using a non-invasive measure of exposure.

Methods We recruited 180 participants (73 males, 107 females) aged 18–83 years. Digital imaging of skin hyperpigmentation (skin damage) and skin wrinkling (skin aging) on the facial region was measured. Lifetime sun exposure (presented as hours) was calculated from the participants' age multiplied by the estimated annual time outdoors for each year of life. We analyzed the effects of lifetime sun exposure on skin damage and skin aging. We adjust for the influence of age, sex, occupation, history of skin cancer, eye color, hair color, and skin color.

Results There were non-linear relationships between lifetime sun exposure and skin damage and skin aging. Younger participant's skin is much more sensitive to sun exposure than those who were over 50 years of age. As such, there were negative interactions between lifetime sun exposure and age. Age had linear effects on skin damage and skin aging.

Conclusion The data presented showed that self reported lifetime sun exposure was positively associated with skin damage and skin aging, in particular, the younger people. Future health promotion for sun exposure needs to pay attention to this group for skin cancer prevention messaging.