综述|重复经颅磁刺激治疗帕金森病言语障碍研究进展
2024-05-11 中国神经精神疾病杂志 中国神经精神疾病杂志
rTMS在PD言语障碍的治疗中取得了良好的效果,但目前研究的数量较少,未来还需要更多大规模和大样本量的随机对照试验来进一步验证和支持其效果。
摘 要 帕金森病(Parkinson disease,PD)患者多数会出现言语功能障碍,严重影响生活质量。近年重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)在治疗PD患者言语障碍的临床实践中取得了新的进展。研究结果提示,将rTMS作用于初级运动皮质(primary motor cortex,M1)的口面部区域和颞上回(superior temporal gyrus,STG)可能会有效地改善PD患者的言语功能,现有研究未见报道有由rTMS引起的严重不良反应。rTMS治疗PD患者言语障碍的机制可能与rTMS可以调节言语相关大脑皮质(如M1和STG)的兴奋性和功能连接程度有关。总结来说,rTMS在PD言语障碍的治疗中取得了良好的效果,但目前研究的数量较少,未来还需要更多大规模和大样本量的随机对照试验来进一步验证和支持其效果。 关键词 帕金森病;言语障碍;经颅磁刺激;运动皮质;颞叶;前额叶皮质 1. DASHTIPOUR K, TAFRESHI A, LEE J, et al. Speech disorders in Parkinson's disease: Pathophysiology, medical management and surgical approaches[J]. Neurodegener Dis Manag, 2018, 8(5): 337-348. 2. ROHL A, GUTIERREZ S, JOHARI K, et al. Speech dysfunction, cognition, and Parkinson's disease[J]. Prog Brain Res, 2022, 269(1): 153-173. 3. MUÑOZ-VIGUERAS N, PRADOS-ROMÁN E, VALENZA M C, et al. Speech and language therapy treatment on hypokinetic dysarthria in Parkinson disease: Systematic review and meta-analysis[J]. Clin Rehabil, 2021, 35(5): 639-655. 4. 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Seizures from transcranial magnetic stimulation 2012-2016: Results of a survey of active laboratories and clinics[J]. Clin Neurophysiol, 2019, 130(8): 1409-1416. 31. 张梁英, 王永军. 重复经颅磁刺激治疗阿尔茨海默病的刺激参数及作用机制研究进展[J]. 神经疾病与精神卫生, 2023, 23(12): 874-878.1 rTMS治疗PD言语障碍的刺激部位及疗效
2 rTMS治疗PD言语障碍的潜在机制
3 安全性问题
4 小结与展望
作者:中国神经精神疾病杂志
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#帕金森病# #重复经颅磁刺激# #言语障碍#
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