Cell Microbiol：有关疟原虫释放蛋白的知识更新
2014-01-20 胡添（译） 医学界网站
摘要： 疟疾的症状是由疟原虫感染人类血红细胞（RBCs）导致的。RBCs因为缺乏其他正常细胞内的反应过程和物质，所以为疟原虫提供了得天独厚的环境。正因为如此，疟原虫属类病原生物通过分泌几百种蛋白来适应并重塑各种各样的宿主细胞，这些蛋白功能各异，其中最被人们熟知的是毒力相关性蛋白。许多其分泌的蛋白自身组成RBC内一新异常系统，该系统继而促进蛋白分泌。在本综述中，我们对寄生虫生成的分泌蛋白机制以及由
摘要：
疟疾的症状是由疟原虫感染人类血红细胞（RBCs）导致的。RBCs因为缺乏其他正常细胞内的反应过程和物质，所以为疟原虫提供了得天独厚的环境。正因为如此，疟原虫属类病原生物通过分泌几百种蛋白来适应并重塑各种各样的宿主细胞，这些蛋白功能各异，其中最被人们熟知的是毒力相关性蛋白。许多其分泌的蛋白自身组成RBC内一新异常系统，该系统继而促进蛋白分泌。在本综述中，我们对寄生虫生成的分泌蛋白机制以及由该机制识别并分类的分泌蛋白的最新研究进展进行总结性概述。
原文出处：
Elsworth B, Crabb BS, Gilson PR.Protein export in malaria parasites: an update.Cell Microbiol. 2014 Jan 13. doi: 10.1111/cmi.12261.
Astract
Symptomatic malaria is caused by the infection of human red blood cells (RBCs) with Plasmodium parasites. The RBC is a peculiar environment for parasites to thrive in as they lack many of the normal cellular processes and resources present in other cells. Because of this, Plasmodium spp. have adapted to extensively remodel the host cell through the export of hundreds of proteins that have a range of functions, the best known of which are virulence-associated. Many exported parasite proteins are themselves involved in generating a novel trafficking system in the RBC that further promotes export. In this review we provide an overview of the parasite synthesised export machinery as well as recent developments in how different classes of exported proteins are recognised by this machinery.
Astract
Symptomatic malaria is caused by the infection of human red blood cells (RBCs) with Plasmodium parasites. The RBC is a peculiar environment for parasites to thrive in as they lack many of the normal cellular processes and resources present in other cells. Because of this, Plasmodium spp. have adapted to extensively remodel the host cell through the export of hundreds of proteins that have a range of functions, the best known of which are virulence-associated. Many exported parasite proteins are themselves involved in generating a novel trafficking system in the RBC that further promotes export. In this review we provide an overview of the parasite synthesised export machinery as well as recent developments in how different classes of exported proteins are recognised by this machinery.
作者：胡添（译）
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