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objectCover=https://img.medsci.cn/20240123/1706014721840_5610093.jpg, objectUrl=/article/show_article.do?id=80a78106e249, replyNumber=0, likeNumber=0, createdTime=2024-01-24, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=80a78106e249, moduleTitle=J Pharm Pharmacol：龙葵碱通过ALOX12B/ADCY4分子轴诱导结直肠癌细胞铁死亡, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=80a78106e249)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2177744, encodeId=2d6421e774442, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a> <a href='/topic/show?id=e9de109336c4' target=_blank style='color:#2F92EE;'>#数字病理#</a> <a href='/topic/show?id=e0fe1083662b' target=_blank style='color:#2F92EE;'>#癌症基因组图谱#</a>, objectTitle=利用CRC组织切片检测MSI，Owkin将与默克合作开发AI驱动的数字病理诊断, objectType=article, longId=807087, objectId=cf7f80e0879d, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/dna-art2.jpg, objectUrl=/article/show_article.do?id=cf7f80e0879d, replyNumber=0, likeNumber=99, createdTime=2023-12-28, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=cf7f80e0879d, moduleTitle=利用CRC组织切片检测MSI，Owkin将与默克合作开发AI驱动的数字病理诊断, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=cf7f80e0879d)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2163772, encodeId=a4322163e723d, content=<a href='/topic/show?id=e1661e2405c' target=_blank style='color:#2F92EE;'>#TDS#</a>阳性的肿瘤具有更多的侵略性生物学行为，导致<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a><a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>的无病生存率和总生存率较低。对于TDs阳性的早期直肠肿瘤，临床上建议采用<a href='/topic/show?id=a6e3295e43e' target=_blank style='color:#2F92EE;'>#全直肠系膜切除术#</a>作为根治性手术方法。研究表明，<a href='/topic/show?id=b4975869e17' target=_blank style='color:#2F92EE;'>#新辅助化疗#</a>可以减少直肠癌的肿瘤沉积，将TDs状态由阳性变为阴性、减少局部复发率。, objectTitle=academic radiology：CT放射组学模型，实现结直肠癌的术前无创风险分层！, objectType=article, longId=796775, objectId=0ec6e9677594, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/202301009/1696894056775_4754896.jpeg, objectUrl=/article/show_article.do?id=0ec6e9677594, replyNumber=0, likeNumber=112, createdTime=2023-10-19, rootId=0, userName=litao2022, userId=1ff65466529, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=0ec6e9677594, moduleTitle=academic radiology：CT放射组学模型，实现结直肠癌的术前无创风险分层！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=0ec6e9677594)], followStatus=false, userIsMember=true, type=1, lengthMark=0), GetTopicListResponse(id=2163027, encodeId=29f5216302e39, content=中药<a href='/topic/show?id=1ded10e0037b' target=_blank style='color:#2F92EE;'>#复方蟾灵膏#</a>(CLG)具有滋阴散瘤、清热解毒、活血化瘀等功效，在临床实践中已被证明具有良好的抗肿瘤作用。前期急性毒性实验和长期毒理学实验表明，CLG可以作为长期临床用药安全使用。CLG对移植了<a href='/topic/show?id=db1c10e0040d' target=_blank style='color:#2F92EE;'>#LOVO细胞#</a>和肝转移瘤的<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>/BALB/c裸鼠具有<a href='/topic/show?id=fb9c10e005d4' target=_blank style='color:#2F92EE;'>#特异性抑制#</a>作用。尽管CLG具有突出的临床疗效，但其作用机制仍需继续研究。, objectTitle=Environ Toxicol：蟾灵膏通过调节PI3K/Akt/mTOR通路抑制结直肠癌，提高生存质量, objectType=article, longId=796343, objectId=d3bce963430f, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/202301015/1697374603627_5610093.jpg, objectUrl=/article/show_article.do?id=d3bce963430f, replyNumber=0, likeNumber=114, createdTime=2023-10-16, rootId=0, userName=litao2022, userId=1ff65466529, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=d3bce963430f, 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style='color:#2F92EE;'>#CRC#</a>, objectTitle=“免疫双子星”布局结直肠癌辅助、后线治疗战力拉满！快看CRC新进展~, objectType=article, longId=731877, objectId=f7c0e318771d, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=f7c0e318771d, replyNumber=0, likeNumber=105, createdTime=2023-02-14, rootId=0, userName=yxch36, userId=4cea26, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=f7c0e318771d, moduleTitle=“免疫双子星”布局结直肠癌辅助、后线治疗战力拉满！快看CRC新进展~, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=f7c0e318771d)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1827274, encodeId=53e2182e27437, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, objectTitle=Front Oncol：非转移性非透明细胞肾细胞癌(non-ccRCC)患者的临床特征和临床预后差异, objectType=article, longId=293862, objectId=e5bc2938625c, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=e5bc2938625c, replyNumber=0, likeNumber=86, createdTime=2022-07-05, rootId=0, userName=yxch36, userId=4cea26, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=e5bc2938625c, moduleTitle=Front Oncol：非转移性非透明细胞肾细胞癌(non-ccRCC)患者的临床特征和临床预后差异, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=e5bc2938625c)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1827280, encodeId=ff83182e28071, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, objectTitle=J Clin Oncol：MSS和MGMT缺失转移性结直肠癌（mCRC）使用替莫唑胺以及联合低剂量伊匹木单抗和那武利尤单抗治疗的疗效, objectType=article, longId=300870, objectId=d1753008e0b3, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=d1753008e0b3, replyNumber=0, likeNumber=89, createdTime=2023-01-08, rootId=0, userName=yxch36, userId=4cea26, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=d1753008e0b3, moduleTitle=J Clin Oncol：MSS和MGMT缺失转移性结直肠癌（mCRC）使用替莫唑胺以及联合低剂量伊匹木单抗和那武利尤单抗治疗的疗效, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=d1753008e0b3)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1827286, encodeId=5dff182e2862b, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, objectTitle=J Clin Oncol：mFOLFOXIRI+帕尼单抗对比FOLFOX+帕尼单抗一线治疗RAS和BRAF野生型转移性结直肠癌(mCRC)的疗效, objectType=article, longId=729659, objectId=add1e2965928, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=add1e2965928, replyNumber=0, likeNumber=98, createdTime=2022-08-12, rootId=0, userName=yxch36, userId=4cea26, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=add1e2965928, moduleTitle=J Clin Oncol：mFOLFOXIRI+帕尼单抗对比FOLFOX+帕尼单抗一线治疗RAS和BRAF野生型转移性结直肠癌(mCRC)的疗效, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=add1e2965928)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

CRC

2020-05-29

梅斯管理员 (审核中...)

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#结直肠癌# #CRC# #肠道微生物# #水平基因转移#

NAR：港城大李帅成团队开发水平基因转移检测新算法，揭示肠道微生物水平基因转移和CRC的功能关联

2024-06-30发表于上海

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#结肠癌# #胰腺癌# #CRC# #KRAS# #PDAC#

读书报告 | AMPLIFY-201研究：淋巴结靶向性KRAS疫苗治疗胰腺癌和结肠癌的I期临床研究

2024-04-26发表于陕西省

梅斯管理员 (审核中...)

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#CRC# #铁死亡# #ALOX12B/ADCY4# #龙葵碱#

J Pharm Pharmacol：龙葵碱通过ALOX12B/ADCY4分子轴诱导结直肠癌细胞铁死亡

2024-01-24发表于上海

梅斯管理员 (审核中...)

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#CRC# #数字病理# #癌症基因组图谱#

利用CRC组织切片检测MSI，Owkin将与默克合作开发AI驱动的数字病理诊断

2023-12-28发表于上海

(审核中...)

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#TDS#阳性的肿瘤具有更多的侵略性生物学行为，导致#CRC##结直肠癌#的无病生存率和总生存率较低。对于TDs阳性的早期直肠肿瘤，临床上建议采用#全直肠系膜切除术#作为根治性手术方法。研究表明，#新辅助化疗#可以减少直肠癌的肿瘤沉积，将TDs状态由阳性变为阴性、减少局部复发率。

academic radiology：CT放射组学模型，实现结直肠癌的术前无创风险分层！

2023-10-19发表于上海

(审核中...)

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全文收起中药#复方蟾灵膏#(CLG)具有滋阴散瘤、清热解毒、活血化瘀等功效，在临床实践中已被证明具有良好的抗肿瘤作用。前期急性毒性实验和长期毒理学实验表明，CLG可以作为长期临床用药安全使用。CLG对移植了#LOVO细胞#和肝转移瘤的#CRC#/BALB/c裸鼠具有#特异性抑制#作用。尽管CLG具有突出的临床疗效，但其作用机制仍需继续研究。

Environ Toxicol：蟾灵膏通过调节PI3K/Akt/mTOR通路抑制结直肠癌，提高生存质量

2023-10-16发表于上海

(审核中...)

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#锯齿状病变#是一种以隐窝上皮呈现锯齿状外观为特征的#癌前病变#，通常位于#近端结肠#，外形隐蔽，普通内镜下很难发现，因此有研究认为发生在#结肠镜#筛查后的 #CRC# 可能是由漏检和未处理的锯齿状病变发展而来

JGH：中国结肠镜检查患者无柄锯齿状病变的危险因素分析

2023-10-11发表于上海

yxch36 (审核中...)

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#CRC#

【今晚直播】mCRC整体治疗原则及2022年度进展

2022-12-30

yxch36 (审核中...)

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#CRC#

CRC:睾酮、认知功能减退与老年男性痴呆的关系

2023-02-13

yxch36 (审核中...)

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#CRC#

Oncologist：西妥昔单抗+伊立替康+贝伐单抗联合治疗未能改善伊立替康难治性转移性结直肠癌(mCRC)的患者PFS，但可改善OS

2022-07-05

yxch36 (审核中...)

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#CRC#

Front Oncol：国内多中心评估Regorafenib（瑞戈非尼）三线或以上治疗难治性转移性结直肠癌（mCRC）患者的疗效

2023-03-14

yxch36 (审核中...)

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#CRC#

Cancers：dMMR/MSI转移性结直肠癌（mCRC)治疗失败后使用传统治疗（CT，化疗联合或不联合靶向治疗）治疗的疗效

2022-04-27

yxch36 (审核中...)

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#CRC#

CRC：高血糖联合莫西沙星对男性和女性1型糖尿病患者心脏复极的影响

2022-10-29

yxch36 (审核中...)

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#CRC#

Oncologist：RAS/BRAF野生型转移性结直肠癌(mCRC)患者中以抗EGFR为基础的再诱导治疗的疗效

2022-07-22

yxch36 (审核中...)

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#CRC#

Br J Cancer：转移性结直肠癌(mCRC)伴有腹膜转移(PM)患者进行细胞减瘤手术(CRS)和腹腔热灌注化疗(HIPEC)时BRAF、KRAS和MSI对其影响

2022-08-24

yxch36 (审核中...)

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#CRC#

Front Oncol：III期临床研究XELAVIRI评估一线贝伐珠单抗为基础的续观治疗对比联合治疗转移性结直肠癌（mCRC）患者的疗效

2022-11-05

yxch36 (审核中...)

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#CRC#

“免疫双子星”布局结直肠癌辅助、后线治疗战力拉满！快看CRC新进展~

2023-02-14

yxch36 (审核中...)

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#CRC#

Front Oncol：非转移性非透明细胞肾细胞癌(non-ccRCC)患者的临床特征和临床预后差异

2022-07-05

yxch36 (审核中...)

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#CRC#

J Clin Oncol：MSS和MGMT缺失转移性结直肠癌（mCRC）使用替莫唑胺以及联合低剂量伊匹木单抗和那武利尤单抗治疗的疗效

2023-01-08

yxch36 (审核中...)

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#CRC#

J Clin Oncol：mFOLFOXIRI+帕尼单抗对比FOLFOX+帕尼单抗一线治疗RAS和BRAF野生型转移性结直肠癌(mCRC)的疗效

2022-08-12

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