circRNA-话题@MedSci

#circRNA#

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lengthMark=0), GetTopicListResponse(id=2189683, encodeId=7f1e21896832d, content=<a href='/topic/show?id=35c21222496' target=_blank style='color:#2F92EE;'>#mRNA#</a> <a href='/topic/show?id=e8284e469c' target=_blank style='color:#2F92EE;'>#circRNA#</a> <a href='/topic/show?id=9ef211162127' target=_blank style='color:#2F92EE;'>#环状 RNA#</a>, objectTitle=Nature：揭示环状 RNA从细胞核中运出机制, objectType=article, longId=814737, objectId=9b49814e3780, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/bioon-com/20240225/1708838572635_2185383.png, objectUrl=/article/show_article.do?id=9b49814e3780, replyNumber=0, likeNumber=68, createdTime=2024-02-27, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2188276, encodeId=ff7421882e68f, content=<a href='/topic/show?id=735a81364b7' target=_blank 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target=_blank style='color:#2F92EE;'>#环状RNA#</a>的<a href='/topic/show?id=aa308e8307e' target=_blank style='color:#2F92EE;'>#药物研发#</a>将是未来的巨大方向，它会超过目前的mRNA，不过目前mRNA技术仍然可以用于环状RNA，包括<a href='/topic/show?id=5fc38e884f8' target=_blank style='color:#2F92EE;'>#药物递送#</a>的技术。<a href='/topic/show?id=7c1010285035' target=_blank style='color:#2F92EE;'>#魏文胜#</a>是中国本土的环状RNA的领军人物，创办了<a href='/topic/show?id=64a31068603b' target=_blank style='color:#2F92EE;'>#圆因生物#</a>，另外，<a href='/topic/show?id=6a49106861e7' target=_blank style='color:#2F92EE;'>#环码生物#</a>和<a href='/topic/show?id=54c11068628a' target=_blank style='color:#2F92EE;'>#科锐迈德#</a>也是很有潜力的公司，都值得关注。根据<a href='/topic/show?id=e8284e469c' target=_blank style='color:#2F92EE;'>#circRNA#</a>的特点，它既可以作为编码新的蛋白使用，甚至将来还可以编码出“<a href='/topic/show?id=2075e738417' target=_blank style='color:#2F92EE;'>#纳米抗体#</a>”的可能，因此，有望用于包括<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>在内的各类疾病。当然，这有赖于技术的全面发展，成本的降低。包括：利用<a href='/topic/show?id=d3a024808e0' target=_blank style='color:#2F92EE;'>#人工智能#</a>技术合成更有效，免疫原性更低的circRNA，以及更便宜的成药方法和使用方法，另外就是特异性要更强，要针对非常特定的蛋白质（如突变的蛋白质）进行设计，这样副作用可能更低。这样它的潜力就能最大化地发挥。, objectTitle=Nature：环状RNA可能是下一代重磅药物研发方向？, objectType=article, longId=795369, objectId=8a77e9536938, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20230930/d0050db8c6bb41d2aa7ec488b2582f4d.jpg, objectUrl=/article/show_article.do?id=8a77e9536938, replyNumber=0, likeNumber=169, createdTime=2023-10-10, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=8a77e9536938, moduleTitle=Nature：环状RNA可能是下一代重磅药物研发方向？, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=8a77e9536938)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=1545484, encodeId=261a154548409, content=<a href='/topic/show?id=e8284e469c' target=_blank 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circRNA

2020-05-29

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#癌症# #环状RNA# #circRNA#

Nat Rev Cancer综述：环状RNA——癌症研究新前沿

2024-08-30发表于上海

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#胃癌# #淋巴结转移# #circRNA#

‌Oncogene：河北医科大学赵群/孟令娇合作发现新型circRNA在胃癌中促进淋巴结转移

2024-08-21发表于上海

梅斯管理员 (审核中...)

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#circRNA# #腹膜纤维化#

论文解读 | Na Liu教授团队揭示circRNA在腹膜纤维化中的作用机制

2024-07-25发表于上海

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#mRNA# #circRNA# #环状 RNA#

2024-02-27发表于上海

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#肝细胞癌# #HCC# #circRNA#

Adv Sci：浙江大学徐骁等团队合作发现肝细胞癌转移调控新机制

2024-02-20发表于上海

侠胆医心 (审核中...)

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全文收起 #环状RNA#的#药物研发#将是未来的巨大方向，它会超过目前的mRNA，不过目前mRNA技术仍然可以用于环状RNA，包括#药物递送#的技术。#魏文胜#是中国本土的环状RNA的领军人物，创办了#圆因生物#，另外，#环码生物#和#科锐迈德#也是很有潜力的公司，都值得关注。根据#circRNA#的特点，它既可以作为编码新的蛋白使用，甚至将来还可以编码出“#纳米抗体#”的可能，因此，有望用于包括#肿瘤#在内的各类疾病。当然，这有赖于技术的全面发展，成本的降低。包括：利用#人工智能#技术合成更有效，免疫原性更低的circRNA，以及更便宜的成药方法和使用方法，另外就是特异性要更强，要针对非常特定的蛋白质（如突变的蛋白质）进行设计，这样副作用可能更低。这样它的潜力就能最大化地发挥。

Nature：环状RNA可能是下一代重磅药物研发方向？

2023-10-10发表于上海

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#circRNA#

circRNADb：汇总编码蛋白环状RNA的数据库

2016-10-17

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#circRNA#

Cell：陈玲玲全面综述circRNA的表征、功能及应用

2022-05-24

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#circRNA#

肿瘤诊断标志物——CircRNA

2021-12-19

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#circRNA#

Cell Death Dis：circRNA-002178充作ceRNA促进肺腺癌PDL1/PD1表达

2020-04-04

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#circRNA#

Clinica Chimica Acta：基于circRNA芯片筛选Kashin-Beck病和骨关节炎患者之间差异表达的circRNA

2020-02-08

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#circRNA#

Cell Death Dis：CircRNA-5692可抑制肝细胞癌进展

2019-12-12

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#circRNA#

Clin Chem：细胞外囊泡长片段RNA测序显示人类血液中含有丰富的mRNA、circRNA和lncRNA，可作为癌症诊断的潜在生物标志物

2019-08-05

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#circRNA#

Biomed Pharmacother：Hsa_circRNA_33287通过miR-214-3p/Runx3促进上颌窦膜干细胞的成骨分化

2018-12-28

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#circRNA#

Front Microbiol：研究发现参与宫颈癌发生的新的lncRNA和circRNA

2017-10-06

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#circRNA#

Sci Rep：抑制miR-26b-5p有助于circRNA_000203的促心肌纤维化的作用

2017-09-18

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#circRNA#

Oncotarget：生殖干细胞中共表达及ceRNA网络相关的lncRNAs和circRNAs的表达谱

2017-09-18

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#circRNA#

Sci Rep：研究初步揭示胃癌组织circRNAs的表达谱

2017-09-06

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#circRNA#

环状RNA（circRNA）背景、特征以及在临床疾病中的应用

2015-12-05

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